Relative efficacy of topical non-steroidal anti-inflammatory drugs and topical capsaicin in osteoarthritis members


Pain is the most troubling issue for people with osteoarthritis (OA), yet current pharmacological treatments offer only small-to-moderate pain reduction. Current guidelines therefore emphasise the need to identify predictors of treatment response. In line with these recommendations, an individual patient data (IPD) meta-analysis will be conducted. The study aims to investigate the relative treatment effects of topical non-steroidal anti-inflammatory drugs (NSAIDs) and topical capsaicin in OA and to identify patient-level predictors of treatment response.


IPD will be collected from randomised controlled trials (RCTs) of topical NSAIDs and capsaicin in OA. Multilevel regression modelling will be conducted to determine predictors for the specific and the overall treatment effect.


Data collection in process. Expected: 15 trials (approximately 3800 participants)

Protocol and publications


M. (Monica) S.M. Persson 1,2
Y. (Yu) Fu 3
A. (Archan) Bhattacharya 4
S. (Siew-Li) Goh 1 4,5
M. (Marienke) van Middelkoop 6
S. (Sita) M.A. Bierma-Zeinstra 6
D. (David) Walsh 1,2
M. (Michael) Doherty 1,2
W. (Weiya) Zhang 1,2

1. Academic Rheumatology, Clinical Sciences Building, Nottingham City Hospital, Nottingham, UK
2. Arthritis Research UK Pain Centre, Nottingham, UK
3. School of Healthcare, University of Leeds, Leeds, UK
4. Arthritis UK Centre for Sports, Exercise and Osteoarthritis, Nottingham, UK
5. Sports Medicine Unit, University of Malaya, Malaysia
6. Erasmus MC Medical University Center Rotterdam, Department of General Practice, The Netherlands